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This review we will focus on the effects resulting from GLP-1 receptor activation in islets of Langerhans Keywords: GLP-1 receptor, exendin-4, insulin synthesis and secretion, exendin (9-39), beta cell, islet of Langerhans, proliferation, differentiation, cAMP, PKA, Epac, PI3 kinase, FoxO1, IRS2, PDX-1 1

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